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COMPARISON OF OUTCOME OF AUTOLOGOUS SERUM THERAPY VS LEVOCETRIZINE IN THE TREATMENT OF CHRONIC URTICARIA

Interventional
Start Date: February 1, 2025
End Date: July 1, 2025
Trial ended

Urticaria

Identification of Subpopulations of Patients With Cholinergic Urticaria Based on the Results of Infrared Exposure

Interventional
Start Date: May 30, 2025
End Date: April 7, 2026
Trial ended

Urticaria

Hôpital Saint-Eloi UCARE

France

Real-world Evaluation of the Effectiveness of Immunoglobulin-Histamine Complex; IHC (Histoglob) in the Management of Chronic Urticaria: A Prospective, Multicenter, Observational Study.

Observational
Start Date: December 31, 2025
End Date: September 1, 2026
16 days until trial ends

Urticaria

Aarvya Hospital

India

+ 35 more locations

A Phase 2 Study to Evaluate the Safety, Tolerability, and Clinical Activity of BLU-808, a Wild Type KIT Inhibitor, in Chronic Inducible Urticaria and Chronic Spontaneous Urticaria

Interventional
Start Date: May 28, 2025
End Date: December 31, 2026
137 days until trial ends

Urticaria

Azienda Ospedale Università di Padova UCARE

Italy

Chang Gung Memorial Hospital UCARE

Taiwan

Charité - Universitätsmedizin Berlin UCARE

Germany

Endeavor Health UCARE

United States

Goethe-Universität Frankfurt am Main UCARE

Germany

+ 42 more locations

An Outpatient, Randomized, Double-Blinded, Placebo-Controlled, Cross-Over Study of the Efficacy of ARS-2 in Patients With Chronic Spontaneous Urticaria

Interventional
Start Date: July 9, 2025
End Date: June 1, 2026
Trial ended

Urticaria
Chronic Urticaria

Charité - Universitätsmedizin Berlin UCARE

Germany

Endeavor Health UCARE

United States

University of Cincinnati, College of Medicine UCARE

United States

Comparative Efficacy of Standard-Dose Versus Updosed Cetirizine in Acute Urticaria: A Randomized Controlled Trial

Interventional
Start Date: November 15, 2025
End Date: June 1, 2026
Trial ended

Urticaria

University of Phayao Hospital

Thailand

A Phase 3 Randomized, Double-Blind, Placebo-Controlled, Multi-Center, Parallel-Group Study of Barzolvolimab in Participants With Cold Induced Urticaria and Symptomatic Dermographism (EMBARQ-COLDU and SD)

Interventional
Start Date: January 15, 2026
End Date: June 1, 2028
655 days until trial ends

Urticaria
Symptomatic dermographism

Charité - Universitätsmedizin Berlin UCARE

Germany

Clínica Universidad de Navarra UCARE

Spain

Elbe Klinikum Buxtehude UCARE

Germany

Johns Hopkins University SOM UCARE

United States

+ 68 more locations

Extending Omalizumab Treatment Intervals in Patients With Chronic Spontaneous Urticaria (EXOTIC Trial): a Multicentre, Randomized, Open-label, Non-inferiority Trial

Interventional
Start Date: January 12, 2024
End Date: December 31, 2025
Trial ended

Urticaria
Chronic Urticaria

Copenhagen University Hospital UCARE

Denmark

Efficacy and Safety of Cetirizine Hydrochloride Injection in the Treatment of Acute Urticaria: a Randomized, Double-blind, Positive Controlled, Multicenter Phase III Clinical Study

Interventional
Start Date: April 22, 2024
End Date: August 1, 2025
Trial ended

Urticaria

HKU Immunology & Allergy UCARE

China

RELIEF: Remibrutinib in Chronic Spontaneous Urticaria: Early Real World Effectiveness and Satisfaction Survey

Observational
Start Date: January 17, 2026
End Date: September 30, 2026
45 days until trial ends

Urticaria

Novartis

United States

A PHASE 2B RANDOMIZED, DOUBLE-BLIND, 12-WEEK PLACEBO-CONTROLLED STUDY WITH A 12-WEEK DOUBLE-BLIND EXTENSION PERIOD TO EVALUATE THE EFFICACY, SAFETY AND TOLERABILITY OF RITLECITINIB (PF-06651600) IN ADULT PARTICIPANTS WITH CHRONIC SPONTANEOUS URTICARIA

Interventional
Start Date: October 30, 2025
End Date: December 25, 2026
131 days until trial ends

Urticaria
CSU
Chronic Urticaria

Alberta Derma Surgery Centre UCARE

Canada

Chang Gung Memorial Hospital UCARE

Taiwan

Charité - Universitätsmedizin Berlin UCARE

Germany

+ 64 more locations

A Randomized, Double-Blind, Sponsor-Open, Placebo-Controlled, First-In-Human, Phase 1 Study of Orally Administered EDP-978 to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Ascending Doses, Multiple Ascending Doses, and the Effect of Food on EDP-978 Pharmacokinetics in Healthy Adult Participants

Interventional
Start Date: April 1, 2026
End Date: November 1, 2026
77 days until trial ends

Urticaria
CSU
Chronic Urticaria

ICON Early Phase

United States

Autologous Whole Blood Therapy in Autologous Serum Skin Test (ASST) Positive and Negative Chronic Idiopathic Urticaria Patients, a Clinical and Biochemical Randomized Controlled Trial.

Interventional
Start Date: April 30, 2026
End Date: September 30, 2026
45 days until trial ends

Urticaria

A 12-week Randomized, Participant and Investigator-blinded, Placebo-controlled, Exploratory Study in Adult Participants With Chronic Urticaria to Assess the Efficacy and Safety and Explore the Mechanism of Action of Remibrutinib (LOU064)

Interventional
Start Date: May 22, 2025
End Date: August 23, 2027
372 days until trial ends

Urticaria
CSU
CIndU
Chronic Urticaria

Endeavor Health UCARE

United States

+ 12 more locations

A Randomized, Double-blind, Placebo-controlled Phase 1/2 Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of HS-10561 Capsule in Healthy Chinese Adults and Patients With Chronic Spontaneous Urticaria.

Interventional
Start Date: March 31, 2025
End Date: September 27, 2026
42 days until trial ends

Urticaria
CSU
Chronic Urticaria

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase II Clinical Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of HRS-3095 in Patients With Chronic Spontaneous Urticaria

Interventional
Start Date: July 1, 2026
End Date: December 1, 2026
107 days until trial ends

Urticaria
CSU
Chronic Urticaria

A Prospective Observational Study of Patients Receiving Dupilumab for Chronic Spontaneous Urticaria

Observational
Start Date: March 18, 2026
End Date: November 24, 2027
465 days until trial ends

Urticaria
CSU
Chronic Urticaria

Virtual Research Coordination Center

United States

A Multicenter, Randomized, Double-blind, Parallel-group, Active-controlled Phase II Clinical Study to Evaluate the Efficacy, Safety and Tolerability of JYB1904 Injection in Adult Patients with Chronic Spontaneous Urticaria Inadequately Controlled by H1 Antihistamines

Interventional
Start Date: August 4, 2024
End Date: July 15, 2026
Trial ended

Urticaria
CSU
Chronic Urticaria

First Hospital Peking UCARE

China

A Randomized, Double-Blind, Placebo-controlled, Multiple-Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, Pharmacodynamics and Clinical Activity of BBT001 Following Intravenous Administration in Adult Patients With Chronic Spontaneous Urticaria.

Interventional
Start Date: June 29, 2026
End Date: December 31, 2027
502 days until trial ends

Urticaria
CSU
Chronic Urticaria

Peking University People's Hospital UCARE

China

+ 5 more locations

Remibrutinib in Real-world Clinical Practice: a Prospective, Multi-country, Non-interventional, Effectiveness and Safety Study - a US Sub-study

Observational
Start Date: February 2, 2026
End Date: September 30, 2029
1141 days until trial ends

Urticaria
CSU
Chronic Urticaria

Cleaver Dermatology

United States

Remibrutinib in Real-world Clinical Practice: a Prospective, Multi-country, Non-interventional, Effectiveness and Safety Study

Observational
Start Date: February 2, 2026
End Date: October 30, 2031
1901 days until trial ends

Urticaria
CSU
Chronic Urticaria

Cleaver Dermatology

United States

A Phase 1, Randomized, Double-blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Single Dose of HRS-3095 in Healthy Participants

Interventional
Start Date: July 30, 2026
End Date: October 15, 2026
60 days until trial ends

Urticaria
CSU
Chronic Urticaria

Veritus Research

Australia

Development and Testing of a Digital Psychological Tool to Improve Symptom Burden in Dermatology Patients

Interventional
Start Date: February 23, 2026
End Date: December 1, 2028
838 days until trial ends

Urticaria

A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Tolerability, Pharmacokinetic, Pharmacodynamic, and Preliminary Efficacy Trial of GTX-B001 in Healthy Volunteers (Part A) and Patients With Chronic Inducible Urticaria (Part B)

Interventional
Start Date: October 6, 2025
End Date: August 1, 2027
350 days until trial ends

Urticaria
CIndU
Symptomatic dermographism
Chronic Urticaria

Charité - Universitätsmedizin Berlin UCARE

Germany

A US Phase 3b, Multi-center, Randomized, Double-blind, Double-Dummy Study to Evaluate Efficacy of Remibrutinib Compared to Dupilumab at Early Timepoints in Adults With Chronic Spontaneous Urticaria Inadequately Controlled by Second Generation H1-Antihistamines

Interventional
Start Date: July 11, 2025
End Date: February 22, 2027
190 days until trial ends

Urticaria
CSU
Chronic Urticaria

Johns Hopkins University SOM UCARE

United States

University of Cincinnati, College of Medicine UCARE

United States

Accellacare Duly Health and Care

United States

Acuro Research Inc

United States

Aeroallergy Research Laboratories

United States

+ 125 more locations

A Phase II/III Randomized, Double-blind, Placebo-controlled, Multi-center Study to Evaluate the Efficacy and Safety of ICP-332 in Moderate to Severe Chronic Spontaneous Urticaria Subjects Inadequately Controlled by Second Generation H1-antihistamines

Interventional
Start Date: February 13, 2026
End Date: September 1, 2028
747 days until trial ends

Urticaria
CSU
Chronic Urticaria

Beijing Tongren Hospital UCARE

China

Beijing Tsinghua Changgung Hospital UCARE

China

China-Japan Friendship Hospital UCARE

China

+ 25 more locations